منابع مشابه
Biocatalytic Friedel–Crafts Acylation and Fries Reaction
The Friedel-Crafts acylation is commonly used for the synthesis of aryl ketones, and a biocatalytic version, which may benefit from the chemo- and regioselectivity of enzymes, has not yet been introduced. Described here is a bacterial acyltransferase which can catalyze Friedel-Crafts C-acylation of phenolic substrates in buffer without the need of CoA-activated reagents. Conversions reach up to...
متن کاملThe enantioselective construction of tetracyclic diterpene skeletons with Friedel-Crafts alkylation and palladium-catalyzed cycloalkenylation reactions.
Due to the profound extent to which natural products inspire medicinal chemists in drug discovery, there is demand for innovative syntheses of these often complex materials. This article describes the synthesis of tricarbocyclic natural product architectures through an extension of the enantioselective Birch-Cope sequence with intramolecular Friedel-Crafts alkylation reactions. Additionally, pa...
متن کاملPhosphorus-Nitrogen Compounds, Part XLV [1] Friedel-Crafts Reactions of Some Aminochlorocyclotriphosphazatrienes*
Chloroaminocyclotriphosphazatrienes, N3P3Cl6-nRn [R = NHMe (n = 2), NHEt ( n = 1, 2), NHPr« (n = 4), NHPr* ( n = 1, 4), NHBu< (n = 2, 4), NHCH2Ph ( n = 1), NEt2 (n= 1, 2, 3), N(CH2Ph)2 (n = 1)] react with benzene in the presence of anhydrous aluminium chloride to give phenylated products: phosphazenes and/or hydrocarbons. The structures of the phenylphosphazenes are assigned from their NMR spec...
متن کاملPi-activated alcohols: an emerging class of alkylating agents for catalytic Friedel-Crafts reactions.
The direct functionalization of aromatic compounds, via Friedel-Crafts alkylation reactions with alcohols, is one of the cornerstones in organic chemistry. The present emerging area deals with the recent advances in the use of pi-activated alcohols in the catalytic and stereoselective construction of benzylic stereocenters.
متن کاملSeleniranium ion-triggered reactions: new aspects of Friedel-Crafts and N-detosylative cyclizations.
Seleniranium ions at low temperatures (-90 to -78 degrees C) will initiate effective Friedel-Crafts cyclization if a suitably placed arene is allowed to react even when the arene is unactivated. These intermediates generated from N-aryl-N-tosylamides undergo a novel, surprisingly efficient, detosylative cyclization to form 5- or 6-membered nitrogen heterocycles. A debenzylation route is preferr...
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ژورنال
عنوان ژورنال: Nature
سال: 1944
ISSN: 0028-0836,1476-4687
DOI: 10.1038/154085a0